Bromelain (Ananas comosus) Alternate names

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Bromelain (Ananas comosus)
Alternate names

Pineapple, A. ananas, A.duckei, A.sativus, Bromelia ananas, Bromelia comosa
Medicinal parts used

Extracted from the stem and the fruit of the pineapple


Bromelain is a sulfur-containing proteolytic digestive enzyme


Bromelain is taken orally:

Possibly Ineffective

Insufficient evidence


Knee pain


Rheumatoid arthritis (RA)



Ulcerative colitis

Urinary tract infections (UTIs)

Likely safe

When used orally and appropriately

Side effects and warnings

The most commonly reported side effects are gastric upset and diarrhea.

Food/drug/herb interactions

  • Zinc

  • Anticoagulant/antiplatelet herbs, supplements, and drugs

  • Amoxicillin

  • Tetracycline antibiotics

  • Potatoes and soybeans contain a protein inhibitor of proteolytic enzymes. In theory, these foods may inhibit bromelain activity.

References and recommended readings
Bromelain. Natural Medicines Comprehensive Database website. Accessed April 14, 2015.
Bromelain. National Center for Complementary and Integrative Health website. Published August 2014. Accessed April 14, 2015.

Review Date: 3/30/15

Contributed by Crystal Petrello, MS, RDN, LD

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