Supplementary Figure 1




Yüklə 30.08 Kb.
tarix28.02.2016
ölçüsü30.08 Kb.
Supplementary Figure 1. Amino acid alignment of cryptochromes and 6-4 photolyases expressed in S2 cells and assayed for transcriptional activity. Abbreviations: Mm, Mus musculus; Dr, Danio rerio; Dp, Danaus plexippus; Ap, Antheraea pernyi; Ag, Anopheles gambiae; Bi, Bombus impatiens; Am, Apis mellifera; Tc, Tribolium castaneum; Dm, Drosophila melanogaster.
Mm mCRY1 ---------- ---------- ---------- -MGVNAVHWF RKGLRLHDNP ALKECIQG-- ------ADTI ------RCVY ILDPWFAGSS NVGINRWRFL LQCLEDLDAN LRKLN---SR [072]

Dp CRY2 -MSVAETLPL -RARS--PTA QKSSQPAG-V PKEKHT.... .......... ..R.GLVD-- ------.T.F ------...F .I.....S.. .....K.... ........K. .....---.. [098]

Ap CRY2a MSAAAETLSA PRARSHVPAA SLTSAPTPRR PHTKHT.... .......... ..R.GLVN-- ------.T.F ------...F .I.....S.. .....K.... ........SS .K...---.. [103]

Ag CRY2 ---------- ---------- ---------- MRDKHT.... .......... ..R.GLR.-- ------.R.F ------...F .I........ .....K.... ....D...R. .....---.. [073]

Tc CRY2 ---------- -------MSG VVGDAGRASK GQDKHM.... .R........ S.R.GLK.-- ------.R.F ------...F V......... .....K.... ........RS .....---.. [086]

Am CRY2 ---------- ---MTGSRSS EINPKEGLYD EG.KHT.... .......... S.R.GLA.-- ------.S.F ------...F V........T .I...K.... ........CS .....---.. [090]

Bi CRY2 ---------- ---MTGSRSS EINPDVTVRG EG.KHT.... .......... S.R.GLT.-- ------.T.F ------...F V........T .....K.... ........CS .....---.. [090]

Dm PHR6-4 ---------- ---------- --------MD SQRSTL.... .......... ..SHIFTA-- ------.NAA PGKYFV.PIF ....GILDWM Q..A...... Q.T.....NQ .....---.. [081]

Dp PHR6-4 ---------- ---------- ---------M TKVASVI... .LD......L ..RNA.NE-- ------.ENR --KQIL.PI. VI..DIKN-- R..C..L... F.S.KN..TS ...I.---T. [076]

Dp CRY1 ---------- ---------- ---------- -.LGGN.I.. .H........ S.HSALED-- -----ASSPF ------FPIF .F.GET..TK M..Y..M.Y. .EA.N...QQ F..YG---GK [073]

Ap CRY1 ---------- ---------- ---------- -.LGGS.L.. .H........ S.HAALED-- -----RSVPF ------FPIF VF.GET..TK L..Y..M.Y. .EA.....NQ FK.YG---GK [073]

Ag CRY1 ---------- ---------- ---------M TIN--NIL.. .H........ S.L.ALKSDC VNQSSE.VKL ------FPIF .F.GES..TR I..Y..MK.. .ES.A...RQ F.D.G---GQ [080]

Dm CRY ---------- ---------- ---------M ATRGAN.I.. .H........ ..LAALAD-- ---KDQGIAL ------IP.F .F.GES..TK ...Y..M... .DS.Q.I.DQ .QAATDGRG. [080]
Mm mCRY1 LFVIRGQPAD VFPRLFKEWN ITKLSIEYDS EPFGKERDAA IKKLATEAGV EVIVRISHTL YDLDKIIELN GGQPPLTYKR FQTLVSKMEP LEMPADTITS DVIGKCMTPL SDDHDEK--Y [190]

Dp CRY2 ...V...... AL.K..R..G T.A.TF.E.P ..Y.RV..HN .MTKCR.V.I Q.TS.V.... .K..D...K. ..KA....HQ ..A.IAS.P. PPSAEP..SL ETLNRAV..I ..N...R--F [216]

Ap CRY2a ...V...... AL.K..R..G T.A.TF.E.P ..Y.RV..HN .TTKCR.V.I N..S.V.... .K......R. ..KA....HQ ..A.IAS.P. PQPAEAP.SI ETLNGAK..V .V...DR--F [221]

Ag CRY2 .......... AL.K.....G T.C.TF.E.P ....RV..HN .SEMCK.L.I ...SAA.... .N.ER...K. ..RA....HQ ..AIIAS.DA PPQ.EAA..L ....NAN..Q Y....D.--. [191]

Tc CRY2 .......... AL.K.....G T.A.TF.E.P ....GV..HN LTT.CQ.L.I S.VQKV.... .H.QD..DR. ..RA....HQ .LAIIAC.G. PPQ.EPPV.F NSLNGAH... T......--. [204]

Am CRY2 .......... AL.K.....G T.N.TF.E.P ....RV..HN .SA.CK.L.I S.VQKV.... .K..E...R. .DK.....HQ ...V.AS.D. P.P.VP.V.. ACV.SAY... KE...DH--. [208]

Bi CRY2 .......... AL.K.....G T.N.TF.E.P ....RV..HN .SA.CK.L.I S.VQKV.... .K..E...R. ..K.....HQ ..NV.AS.D. P.PSVP.V.. AC..SAY... KE...DH--. [208]

Dm PHR6-4 ...V..K..E ....I..S.R VEM.TF.T.I ..YSVT.... VQ...KAE.. R.ETHC...I .NPELVKAK. L.KA.I..QK .LGI.EQLKV PKVLGVPEKL KKMPTPPKDE VEQK.SAA-. [200]

Dp PHR6-4 .Y..K.KAIE CL.K..D..H VKF.TLQV.I DADLVKQ.EV .EEFCEANNI F.VK.MQ..V ..FNSVVKK. N.SI....QK .LS...DVQV KDIIQISKGV SDECKAS--- --.Y.SQG-. [190]

Dp CRY1 .LM.K.R.DL I.R..WE.FG .RT.CF.Q.C ..IWRP...S VRA.CRDI.. SCREHVA... WNP.TV.KA. ..I.....QM .LHT.EIIGN PPR.V.DVDL NGVNFGSL.E .FYREFVVFD [193]

Ap CRY1 .IMLK.K.S. ..R..WE.FG .R..CF.Q.C ..LWRA..DG V.SACR.I.. ACREYV.... WEP.TV.RA. ..I.....QM .LHT.TIVGD PPR.VPDVDM SG.TFGTL.D CFYQEFTVFD [193]

Ag CRY1 .L.F..DSVT .LR...E.L. .K..CY.Q.C ..IW....D. VA..CRTMD. RCVENV.... WNPIEV.QT. .DI.....QM .LHT.NIIGD PPR.VGAPNF EYVEFGRV.A LLASEL.LCQ [200]

Dm CRY .L.FE.E..Y I.R..HEQVR LHRIC..Q.C ..IWN...ES .RS.CR.LNI DFVEKV.... W.PQLV..T. ..I.....QM .LHT.QIIGL PPR.TADARL EDATFVELDP EFCRSL.LFE [200]
Mm mCRY1 GVPSLEELGF DTDGLS---S AVWPGGETEA LTRLERHLER --KAWVANFE RPRMNANSLL ASPTGLSPYL RFGCLSCRLF YFKLTDLYKK VKKN------ -SSPPLSLYG QLLWREFFYT [298]

Dp CRY2 ...T...... ..E..K---P PI.I...N.. .L........ --.....S.G ..K.TPE... S.Q....... ......T... .YQ.SE...R I.Q------- -ER.....H. .I.......C [323]

Ap CRY2a ...T...... E.ED.K---P PM.M...S.. .A..D..... --.....S.G ..K.TPQ... ..Q....... ......T... .YQ..E.... I.R------- -VR.....H. .I.......C [328]

Ag CRY2 ...T...... E.EA.R---P P..I...... .A........ --.....S.G ..K.TPQ... ..Q....... ......T... .YQ....... I..------- -AC.....H. .........C [298]

Tc CRY2 ...T...... ..E.RL---P P..Q...S.. .A........ --.....S.G ..K.TPQ... P.Q....... ......T... .YQ....... I..------- -AF.....H. .........C [311]

Am CRY2 ...T...... ..E..L---P P..V...S.. .A........ --.....S.G ..K.TPQ... P.Q....... ......T... .YQ....... I..------- -AV.....H. .........C [315]

Bi CRY2 ...T...... ..E..L---P P..V...S.. .A........ --.....S.G ..K.TPQ... P.Q....... ......T... .YQ....... I..------- -AV.....H. .........C [308]

Dm PHR6-4 DC.TIKQ.VK RPEE.G---P NKF....... .R.M.ES.KD --EI...R.. K.NTAP...E P.T.V..... K.....A... NQ..KEII.R QP.H------ -.Q..V..I. ..M....Y.. [297]

Dp PHR6-4 DI.....F.V NESE..---E CKY....S.G .K..DVYMAK --.Q..C... K.KSSP..IE P.T.V....I SH....AK.. .H..KQVENG -S.H------ -TL..V..M. ..M....Y.. [306]

Dp CRY1 KA.KP.D..V FLENED-IRM IR.V....A. .KQMQER.AV EYETFCRGSY L.THGNPD.. GP.IS...A. ......V.R. .WS.Q..FQQ .HQG------ RLASTQFIT. ..I...Y... [306]

Ap CRY1 KT.KP.D..V FLENED-IRM IR.V....A. .KQMQQR.AV EHETFRKGSY L.THGSPD.. GP.IS...A. ......V.S. .WSVQ..FRQ .HQG------ RL.SAHFIT. ..I...Y... [317]

Ag CRY1 QM.APDDF.I HY..NARIAF QK.I....R. .EA.GAR.KQ EEE.FREGYY L.TQAKPEI. GPA.SM.AA. ......V.M. .WCVH..FA. .QS.SQFK-- -YPGGHHIT. ..I...Y... [317]

Dm CRY QL.TP.HFNV YG.NMGFLAK IN.R....Q. .LL.DER.KV EQH.FERG.Y L.NQALPNIH D..KSM.AH. ......V.R. .WSVH..F.N .QLRACVRGV QMTGGAHIT. ..I...Y... [320]
Mm mCRY1 AATNNPRFDK MEGNPICVQI PWDK-NPEAL AKWAEGRTGF PWIDAIMTQL RQEGWIHHLA RHAVACFLTR GDLWISWEEG MKVFEELLLD ADWSINAGSW MWLSCSSFFQ QFFH--CYCP [415]

Dp CRY2 ...R..N..R .......... ..E.-.Q... K...N.Q... .......I.. .ND....... .......... .......... ....D..... ....V...M. .......... ....--.... [440]

Ap CRY2a ...R..N..R .......... ..E.-.Q... S...N.Q..Y .......I.. .E........ .......... .......... ....D..M.. ....V...M. .......... ....--.... [445]

Ag CRY2 ...K..T... .A........ ...R-.A... ....S.Q... .......... .E........ .......... .......... .......... ....V...M. .......... ....--.... [415]

Tc CRY2 ...K..N... .I........ ....-.A... ....N.Q... .......... .E........ .......... ....L..... .......... ....V...M. .......... ....--.... [428]

Am CRY2 ...K..N..R .Q........ ....-.V... ....N.Q... .......... .E........ .......... .......... ....D..... ....V...M. .......... ....--.... [432]

Bi CRY2 ...K..N..R .Q........ .G..-.V... ....N.Q... .......... .E........ .......... .......... ....D..... ....V...M. .......... ....--.... [432]

Dm PHR6-4 V.AAE.N..R .L..VY.M.. ..QE-H.DH. EA.TH....Y .F.....R.. .......... .......... .......... QR...Q.... Q..AL...N. ....A.A..H .Y.R--V.S. [425]

Dp PHR6-4 .GSGTEN... .V..SV.T.. ..K.-.DAH. KA....K..Y .FV....R.. K......... ..M....... .......... A....DF... Y...L...N. ....A.A..Y KYYR--V.S. [414]

Dp CRY1 MSV...NYAQ .S.....LD. ..KEPENDE. QR.K...... .FV..A.R.. .T...L..VV .NT..S.... .T..L...H. LQH.LKY... ....VC..N. ..V.S.A.EA LLDSGE.A.. [426]

Ap CRY1 MSV...NYGQ .AD....LD. ..KHPEGDE. QR.I...... .F...A.R.. .A...L..AV .NT..S.... .T..L...H. LNH.LKY... ....VC..N. ..V.S.A.EA LLDSGE.A.. [426]

Ag CRY1 MSVQ..HYGE ..R....LN. ..Y.PEDDS. TR.K...... .M...A.R.. LA...L..IL .NIT.T.... .G..L..... LQH.LKY... ....VC..N. ..V.S.A.ER LLDSSK.T.. [437]

Dm CRY MSV...NY.R ....D..LS. ..A.P.ENL. QS.RL.Q... .L..GA.R.. LA...L..TL .NT..T.... .G..Q...H. LQH.LKY... ....VC..N. ..V.S.A.ER LLDSSLVT.. [440]
Mm mCRY1 VGFGRRTDPN GDYIRRYLPV LRGFPAKYIY DPWNAPEGIQ KVAKCLIGVN YPKPMVNHAE ASRLNIERMK QIYQQLSRYR G------LGL LASVPSNSNG ---------- -NGGLMGYAP [518]

Dp CRY2 .R...K.... ..F..K.I.. .KNM.TR..H E..VC..E.. .SIR.I..KD ..M.I.D.TK ..EI.L..I. .V.A..AKFK --------PQ G.LI.QMLQR ---------- --PNVLQSS. [540]

Ap CRY2a .R...K.... ..F..K.I.A .KNM.TR..H E..V...SV. QA.Q.VV.CD ..L..LD.TK ..QI.L..I. .V.A..AK.K P--------- QVTLQTVQRP ---------- ---NV.QSS. [543]

Ag CRY2 .K...KA... .......... .KN..TRF.H E....S.SV. RA......KD ..L......I ...A.M..I. .V..H.AK.. TPSGGCYE.D CTEKGGSAIA GVMTAAKVQH M.TSS.NDS. [535]

Tc CRY2 IK...KA... .....K.... .KNM.SQ..H E..T...QV. RA...I..KD .SL......A ...V..Q... .V.....N.. ---------- --N.DNSAK- ---------- ----FKDGFQ [521]

Am CRY2 .R...KA... .......... .KN..TR..H E.....LNV. RA...I..KD .SL.....SK S..I...... .V....NK.. --------.N GV.LKGETV. ---------- ----.LNAL. [530]

Bi CRY2 .R...KA... .........I .KN..TR..H E.....LSV. RA...I..KD .SL.....SK S..I...... .V....NK.. --------.N G..LKGETV. ---------- ----.LNAL. [530]

Dm PHR6-4 .A..KK...Q .H...K.V.E .SKY..TC.. E..K.SLVD. RAYG.VL.TD ..HRI.K.EV VHKE..K..G AA.KVNREV. ---------- --TGKEEESS ---------- ----FEEKSE [519]

Dp PHR6-4 .A..KK..KD .L...K.V.E .KKY.SEF.. E..K..K.V. .T.G.I..EG ..NRI.D.DK VHKD..QK.N AA.KVN---- ---------- ----KE---- ---------- ---------- [492]

Dp CRY1 .RL...LE.T .H.V...V.E .ARM.GE... E..R..LEV. EA.G.V..RD ..A.V.D.TA .AAR.RAN.Q ELRRL.EK-- ---------- ---A.PHCC- ---------- ---------- [510]

Ap CRY1 .RL.Q.L..S .E.V...V.E IARM.VD... E..K..LDV. TR.S.I..KH ..A.L...IV .AQR.RNA.. ELR.I.QK-- ---------- ---A.PHCC- ---------- ---------- [510]

Ag CRY1 IALA..L..K ...VK....E .ANY..QFVH E..K.SREQ. IEYG.V..EK ..A...DL.I V.KR.AHT.A SLREK.VDGG ---------- --.T.PHCR- ---------- ---------- [524]

Dm CRY .ALAK.L..D .T..KQ.V.E .MNV.KEFVH E..RMSAEQ. EQYE.....H ..ERIIDLSM .VKR.MLA.. SLRNS.IT-- ---------- ---P.PHCR- ---------- ---------- [524]
Mm mCRY1 GEN------- -----VPSCS SSGNGGLMG- ---------- ---------- ---------Y APGENVPSCS GGNCS----Q GSGILHYAHG DSQQTHSLKQ GRSSAGTGLS SGKRPSQEED [592]

Dp CRY2 SPTS------ ----IIANIN Q.NYLCSQS- ---------- ---------- --------SD V.TPT----- ---------- NQTTNQFKED AVFLKPTVNN IK.NVDKQQQ FKQVVIVQ.. [606]

Ap CRY2a SPTS------ ----IIA.IN Q.NLLCSTT- ---------- ---------- ---------- -.ESQSAATQ MIYKD----P SGIFQRPTKN AVHADTKNTK FKKVLIVHQV KHSEITE.RV [617]

Ag CRY2 SPTTILTSVN SSGNYMCRSN PPAQSDHN.K IITYHQLLSG PDPRSALGGN GSGGDRGNAG V.DDTKHGDG TDGSNHLMAG KES.SQHQQS QL.HS.QAQS LDQQSQENSN .VANSE.RYG [655]

Tc CRY2 E--------- -------Q-- ---------- ---------- ---------- ---------- -.N------- ---------- VVTVGNPSRK *--------- ---------- ---------- [536]

Am CRY2 PSS------- ------MKET EEEKKKTK-- --------QS LSP------- ---------- -SENQSK--- ---------- MEILPKTTQR QHHH*----- ---------- ---------- [571]

Bi CRY2 PPS------- ------VKEN EEEKKKTK-- --------QS PPP------- ---------- -.ENQSK--- ---------- MEVLAKTTQH QQ.HHQHQ*- ---------- ---------- [582]

Dm PHR6-4 TST------- ---------- ---------- ---------- ---------- ---------- -S.------- ---------- KRKVRRATGS APKRKR*--- ---------- ---------- [541]

Dp PHR6-4 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKAMKR---- -PR.*----- ---------- ---------- [502]

Dp CRY1 ---------- ---------- ---------- ---------- ---------- ---------- -.SS------ ---------- EDEVRQ---- ---------- ---------- ---------- [519]

Ap CRY1 ---------- ---------- ---------- ---------- ---------- ---------- -.SS------ ---------- EEE.RQ---- ---------- ---------- ---------- [519]

Ag CRY1 ---------- ---------- ---------- ---------- ---------- ---------- -.SD------ ---------- IEE.RQ---- ---------- ---------- ---------- [533]

Dm CRY ---------- ---------- ---------- ---------- ---------- ---------- -.SN------ ---------- EEEVRQFFWL ADVVV*---- ---------- ---------- [543]
Mm mCRY1 AQSVGPKVQR QSSN*----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [607]

Dp CRY2 KH.ENQRHSV GNKYIVN--- --EINKNIND ---IPVKQNN YDFKALTL-- -----NLN-- --KFSNEPLT FLNQTPNKNE SFGQDVNNVI DVYSTSKPKF YFTDNGVITH NENAQTFKRD [707]

Ap CRY2a S.TNSHHQTP KENYIINSRQ SIEYKTCSDN NLQPPNKHNN YDFKNLVINN HIQGYNNHII YQCQKGNQNE IYSQQGVKTN AYGYENTKFF LSNFADNNIF VSGSPQLYIP GQVNEESPLQ [737]

Ag CRY2 TLP.AEYAAI KPDSLSTLIR AGNLTSAGTR ---FSNLQDQ LSNSLMSL-- -----ECDAL ATKLKPNNYE YERNQNIYNS QFKVEYSDNF NSGYGLRNAV FYGGKREDEN EDTKADNMNN [765]

Tc CRY2 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [536]

Am CRY2 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [571]

Bi CRY2 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [582]

Dm PHR6-4 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [541]

Dp PHR6-4 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [502]

Dp CRY1 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [519]

Ap CRY1 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [519]

Ag CRY1 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [533]

Dm CRY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [543]
Mm mCRY1 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [607]

Dp CRY2 SYSDNYNKES TGSNRVGEVH SNNPQTDKIS SEKKN*---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [743]

Ap CRY2a SNSE-TNNES TKEKTVDLHC INIQSEESFS MENIQNSTTA ESAVNPTNEN EN*------- ---------- ---------- ---------- ---------- ---------- ---------- [789]

Ag CRY2 NHSDQLTGDN SADERAVPND ADDDDESTMT TLQATDAHSA PHALLFAANK SKIKQESLVQ QSSRMFLEPP KHHASRGAKP HRSRCEATEA RSHLADSQVK KEQQITSQAL PPHSMHTDCD [885]

Tc CRY2 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [536]

Am CRY2 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [571]

Bi CRY2 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [582]

Dm PHR6-4 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [541]

Dp PHR6-4 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [502]

Dp CRY1 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [519]

Ap CRY1 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [519]

Ag CRY1 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [533]

Dm CRY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- [543]
Mm mCRY1 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------- [607]

Dp CRY2 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------- [743]

Ap CRY2a ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------- [789]

Ag CRY2 YEPESHKLLA ENYRQQHQQQ QQQQQQQQQQ HEHEQQQQQN SMLATQQRLE ASQMDQGTDQ PMQESPCNEE KIGAGD* [962]

Tc CRY2 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------- [536]

Am CRY2 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------- [571]

Bi CRY2 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------- [582]

Dm PHR6-4 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------- [541]

Dp PHR6-4 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------- [502]

Dp CRY1 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------- [519]

Ap CRY1 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------- [519]

Ag CRY1 ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------- [533]



Dm CRY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------- [543]


Verilənlər bazası müəlliflik hüququ ilə müdafiə olunur ©azrefs.org 2016
rəhbərliyinə müraciət

    Ana səhifə