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K.V.Shakthi narayanah and R.L.Mohan prakash

Department of Biochemistry, R.K.M.Vivekanandha college(unaided), Mylapore.
The rapid replication of HIV-1 and the errors made during viral replication cause the virus to evolve rapidly in patients, making the problems of vaccine development and drug therapy particularly challenging. In the absence of an effective vaccine, drugs are the only useful treatment. Anti-HIV drugs work; so far drug therapy has saved more than three million years of life. Unfortunately, HIV-1 develops resistance to all of the available drugs.. The three viral enzymes, reverse transcriptase (RT), integrase (IN), and protease (PR) are all good drug targets. Two distinct types of RT inhibitors, both of which block the polymerase activity of RT, have been approved to treat HIV-1 infections, nucleoside analogs (NRTIs) and nonnucleosides (NNRTIs). Etravirine and rilpivirine are two new nonnucleoside reverse transcriptase inhibitors (NNRTIs) that have the distinct advantage of being able to be used in patients with exposure to previous NNRTIs (e.g., nevirapine or efavirenz). Etravirine was approved by the United States Food and Drug Administration to be used twice/day in treatment-experienced patients infected with the human immunodeficiency virus. The approval was based on phase III clinical studies in which 61% of etravirine-treated patients reached an undetectable viral load of less than 50 copies/ml compared with 40% of patients who received the optimized background regimen. Etravirine was well tolerated with a self-limiting skin rash being the most common toxicity, reported in 19% of patients. Rilpivirine, a once-daily NNRTI, is entering phase III studies; the drug appears to be effective against a broad range of NNRTI-resistant viruses including etravirine-resistant strains.



K.V.Shakthi Narayanah, Mohan Prakash

Department of Biochemistry,Ramakrishna Mission Vivekananda College,Mylapore.

mylaneeru.myla@gmail.com , ggtarun@yahoo.com

In the present day scientific world, the importance of Gene Cloning and Gene Therapy cannot be underestimated. Gene cloning is the act of making copies, or clones, of a single gene. Once a gene is identified, clones can be used in many areas of biomedical and industrial research. The treatment of genetic diseases by introducing proper genes into patient’s cells is called Gene Therapy.This paper deals with the mechanisms involved in the production of Insulin, Somatotropin, Somatostasin and B-endorphin. The paper also deals with the mechanism of transplantation of Bone Marrow and Liver as part of Gene Therapy.



Ankita Purkayastha

PG Dept. Of Biochemistry,S R M Arts and Science College, Chennai -603203, Tamil Nadu, India.

The concept of nanotechnology was first coined by Richard Feynman in 1959.Nanotechnology refers to manipulation of material at a scale of individual atoms and molecules. Use of specialized bacterium sized “assembler” devices; it permits a programmable control of molecular structures. Definition: Nanotechnology represents a biological process to the manufacture of pharmaceutical and other goods. Nanorobots are nanodevices that will be used for the purpose of maintaining and protecting human body against pathogens. They will have a diameter of about 0.5 to 3.0 microns and with a dimension of 1 to 100 nanometres. The powering of these nanorobots will be done by metabolizing local glucose and oxygen for energy. There are two types of applications-Diagnostic and Therapeutic. Improved Imaging of human body, Nano tracking for tumour detection, Quantum dots emitting wavelength depending upon its size are diagnostic applications. These nano devices can be inhaled directly to lung, which then enters the alveolar duct. There are many therapeutic applications like, Delivering medicine, For example, Organic dedrimers (artificial delivering molecule), hollow polymers (gold coated glass beads), Bc12 family of proteins can be used to destroy harmful cancer cells. These can generate radiation which can kill the bacteria, viruses and other cancerous cells, mimic the natural biological process like repair of damaged tissue, healing of broken bones, transport of oxygen to the body to produce more red blood cells, cure skin diseases, mouthwash full of smart nanomachines can be used to clean the mouth and can remove atherosclerotic plaques preventing heart attacks.



Charles Lekhya Priya and Kokati Venkata Bhaskara Rao *

Molecular and Microbiology Research Lab, Environmental Biotechnology Division, School of Bio Sciences and Technology, VIT University, Vellore-632 014, Tamil Nadu, India.
Diabetes mellitus is a chronic metabolic disorder leading to the raise in blood glucose level resulting in several complications effecting over 346 million people worldwide. Post pandrial hyperglycemia is one of the leading complications of Diabetes mellitus which can be regulated by α-Glucosidase inhibitors. Phytomedicine is well thought to be low toxic and with no side effects. Ethanobotanical studies reveal that over 800 species of medicinal plants are reported to have antidiabetic potential. Acalypha indica (Euphorbiaceae) commonly known as Kuppaimeni is a weed plant growing as an annual herb throughout the Plains of India and traditionally used as a medicine for diabetes. In this study, the aqueous extract of A. indica stem was examined for in vitro and in vivo antidiabetic activities. At a dose of 10 mg/ml, aqueous extract showed 96.6% inhibitory effect on α-Glucosidase in vitro. In vivo antidiabetic activity was carried out in Streptozotocin induced diabetes in Swiss albino rats. Oral administration of aqueous extract at 300 mg/kg body weight reduced blood glucose level by 63.5% in Streptozotocin induced diabetic rats. With all these results we can conclude that aqueous extract of Acalypha indica stem is an effective antidiabetic agent and gives a hope to use herbal medicine as an alternate for treating Diabetes mellitus.



S. Stephen Irudayaraj, C. Sunil, S. Ignacimuthu

Division of Ethnopharmacology,Entomology Research Institute, Loyola College,Chennai-34
Diabetes mellitus (DM) is the most common metabolic disorder affecting millions worldwide. It is recognized as a global major health problem. It is caused by an absolute or relative lack of insulin or reduced insulin activity which results in hyperglycemia and abnormalities in carbohydrate, fat and protein metabolism. It leads to micro vascular (retinopathy, neuropathy, and nephropathy) and macro vascular (heart attack, stroke and peripheral vascular disease) complications. It is estimated that there are approximately 33 million adults with diabetes in India. This number is likely to increase to 57.2 million by the year 2025. Type I diabetes (insulin dependent) is caused due to insulin insufficiency because of lack of functional beta cells. Patients suffering from this are therefore totally dependent on exogenous source of insulin while patients suffering from Type II diabetes (insulin independent) are unable to respond to insulin and can be treated with dietary changes, exercise and medication. Type II diabetes is the more common form of diabetes constituting 90% of the diabetic population. This is one of the main reasons for increasing search for improved antidiabetic drugs. Due to the side effects of the existing synthetic drugs, plants are considered a potential source for the treatment of diabetes and search is on within traditional ethnomedical practices. Although medicinal plants have been traditionally utilized for diabetes treatment, a few of them have been proved by scientific evidence. Of late vast diversity of animal models have been developed for the better grasping of the pathogenesis of DM and new drugs have been launched in the market for treatment. This paper reviews the available methods and animal models to explore the mechanism of action of drugs with potential antidiabetic property by in vivo method.




M.sc, Department of Biochemistry,SRM Arts and Science college,

Kattankulathur 603203

Computational biology is a multidisciplinary area that involves the development and applications of data analytical and theoretical methods, mathematical modelling and computation simulation techniques to the study of biological, behavioural, and social systems. Biomedical image analysis is a fast evolving field driven by the advancement of imaging modalities and high content screening techniques. Many clinical applications are also emerging that use biomedical image processing for decision support. Computational biology which covers the method development and applications, the latter notably in pharmaceutics and medicine. On methodical side we perform research on the analysis of biological sequences(including recombination, viral evolution and computational epigenetic) analysis and prediction of protein structure and function, analysis of intermolecular interactions and interaction net works, gene and protein expression patterns, computational drug screening and drug design. On the application side, we focus on the diseases HIV/AIDS, where we analyze viral drug resistance patterns as well as variants of viral entry into the host cell, HCV/Hepatitis C , where we contribute to uncovering the molecular basis of host –pathogen interactions and neurodegenerative and auto immune disease, where we study underlying protein interaction net works.




M.Sc Department of Biochemistry,SRM Arts and Science College, Kattangulathur 603203.
People who live for 100 years or more with little evidence of a decline in brain function ,many others or not so fortunate and experience a neurodegenerative disorder like Alzheimer disease or Parkinson disease .two incurable brain disorders that take a heavy toll on patients as well as the health care system . Although an increasing number of genetic factors may affect the risk for neurodegenerative disorders are being identified. both disorders involve increased oxidative stress , metabolic impairment, and abnormal protein aggregation .dietary factors play major role in determining whether the brain ages successfully or experiences a neurodegenerative disorder .Dietary factors may interact with disease causing or predisposing genes in molecular cascades that either promote or prevent the degeneration of neurons. Epidemiologic findings suggest that high calorie diets and folic acid deficiency increase the risk for Alzheimer disease and Parkinson disease. Studies on animal models of these disorders have shown (reduced calorie intake or intermittent fasting)and dietary supplementation with folic acid can reduce neuronal damage and improve behavioral outcome .Results from animal studies have shown that the beneficial effects of dietary restriction on the brain increases the production of neurotropic factors and cytoprotective protein chaperones in neurons. Overeating is a major modifiable risk factor for several age-related disease ,including cardio vascular disease and type2 diabetes mellitus .recent findings suggest that calorie intake also influences the risk for Alzheimer’s and Parkinson disease .Dietary restrictions promote neuronal survival, plasticity, and even neurogenesis by inducing a mild cellular stress response that involves activation of genes that encode proteins design to promote neuronal growth and survival.



S.Latha & S.Gunasundari

III-B.Sc Biochemistry, JBAS College for Women-Chennai.

In this study a comparision on antibacterial potency of common weeds i.e. Antigonon leptus, Croton sparsiflorus and Lantana camara were conducted . Antibacterial efficacy on the microorganisms, bacillus subtilis, Escherichia coli, Klebsiella pneumonia, and pseudomonas aeruginosa and Staphylococcus aureus were investigated. For this purpose, the leaf extracts of the plants were prepared using acetone, chloroform, hexane and methanol. The prepared extracts were analysed for its bioefficacy through disc diffusion method. Among the solvent studied, methanolic extract alone given positive results. The hexane and chloroform extract of all the three plants showed poor response in resisting bacterial growth. Among the plants studied, methanolic extract of Lanthanacamara possess greater activity than Croton sparsiflorus and antigonon leptopus.



Sivasankari. V, Shunmuga Priya. S and Sathesh. J

Department of Biotechnology, Sree Sastha Institute of Engineering and Technology, Chennai – 600123.
Alternative medicines cover a broad range of healing philosophies approaches and therapies. It provides powerful cure in treating depression, act as anesthetic, energizing the body’s own healing power and offers hope for certain illness. For example: Herbal medicine, Homeopathy, Yoga therapy, Acupuncture and Ayurveda. Worldwide, only a ten to thirty percent of human health care is delivered by conventional biochemically oriented practitioners. The remaining seventy to ninety percent ranges from self care according to folk principles.

Herbal medicine is the most ancient form of healthcare known. Many drugs that are now considered conventional medications were originally derived from herbs. Homeopathy seeks to cure in accordance with natural laws of healing and uses medicine made from natural substances such as animal, vegetable and minerals. Yoga therapy to address mental and physical problems while integrating body and mind. Acupuncture is an ancient Chinese medicine, based on the idea that the body’s energy must be able to flow smoothly through fourteen major energy channels. Ayurvedic medicine is a system of traditional medicine native to India. Twenty percent of ayurvedic treatments tested contained toxic level of heavy metals such as lead, mercury and arsenic. Others concerns include the use of herbs. Alternative medicines have little to no side effects and each remedy may serve multiple purposes.

Keywords: Alternative medicine, herbal medicine, acupuncture, ayurvedic medicine



Dr.K.Amutha1 and N.P.Roshni2

1.Dr.K.Amutha, M.Sc., Ph.D., Principal Investigator, UGC Major Research Project,

Assistant Professor, Department of Biotechnology,VELS University, Pallavaram, Chennai-117, Tamil Nadu.

2. Roshni, M.Sc.,M.phil., student, Department of Biotechnology,Vels University, Pallavaram, Chennai-117, Tamil Nadu.

Couroupita guianensis is a medical plant, used in several diseases like skin diseases antibiotic, antifungal, antiseptic and analgesic qualities. The juice made from the leaves is used to cure skin diseases. The inside of the fruit can disinfect wounds and young leaves ease toothache. The methanol extract showed high antibacterial activity against Staphylococcus aureus, Bacillus subtilis, E. coli, Klebsiella. The crude methanol solvent extract showed antifungal activity against Aspergillus flavus, A. niger and Pencillium citrium. Four different compounds were obtained from TLC analysis among the four compounds two of them were major fraction, which contains higher Rf values. One of the major compound was partially purified by scrapping and elution method. The wound was created of about 500 mm2 diameter on the dorsal back of testing rats. The C. guianensis water extract ointment treated wounds was compared with control and herbal ointment. The tensile strength indicates better wound healings stimulated by applied herbal formulation. Wherever created the wound, the scar areas were cured with in nine days of period.


A Saraswathy1 22

A. Thenmozhi 26

A. Zakira 60

A.S.Sheeba Malar1 21

Ankita Purkayastha 65

Anusha Bhaskar1 21

Arul selvan K1 43

Arul Selvan K1 43

Arumugam2 36


B Arirudran 22

B.Prasannakumar 66

B.Priyadarshini1 27

B.Revathi 38

B.Sudhagandhi 22

Bhuvaneshwari. S, 47


C. Shanmuga Sundaram 33

C. Sunil 47, 66

C.K.Hindumathy 30

Charles Lekhya Priya 65


D.Anandhi2 21

Devi.R, 49

Devi.R*, 54

Dhanapal sakthisekaran4 46

Dhanapal Sakthisekaran4 38

Dr C.K.Hindhumathy 30

Dr. C.S. Parameswari 24

Dr. Kripa V. Jalapathy 14

Dr. P.Ranjith Rao 19

Dr.C.Padmavathi 38

Dr.K.Amutha1 51, 68

Dr.S.Nagini 13


G. Pramod Reddy2 25

G. Selvamangai2 21

G. Sriram Prasath 34

G.Kumutha 52

Gayathri ,V 31


Hemachitra. P 56

Hindumathy , C.K 31


Inbathamizh.L 23


J. Deepalakshmi 53

J. Kotteshwari2 32

J. Mercy Jasmine1 25

J.Jayapriya1 42, 61

Janaky.S 28

Jancy Mary.E, 23

Jashu javeri 58

Jayanthy.V 57

Jayapriya.J 60, 61, 62, 63

Jhoncy Rani.J, 61


K. HemanthSudheer Kumar 41

K. Revathi1 21

K. Vijayaraghavan 35

K.V.Shakthi narayanah 64


L. Avila Pauline 26

L. Sripriya 54

Lakshmi 30

Lalit R. Samant1 21

Largus Shylee.M 63


M. Hemalatha 28

M. Kandaswamy 34

M.Jeya 36

M.Kasi3 36

M.Kezia Susanna 58

M.Ramila Devi 44

Mainul Haque1 20

Meena. P 50, 58

Meenakshi Sundari .S1 32

Moula Shahjahan 39

Mrs. P.Sreedevi 24

Mrs. S.Vaidehi 1 42

Mrs.Fouzia Banu 40


N.C. Saraswathi2 32

N.K. Udaya Prakash 15, 17, 18

N.K. Udaya Prakash1 32

N.Meena1 36

Neelima Myla 45

Nireesha Gundakaram 29

Nomila Merlin J1 41


P. Anantharaman 25

P. Kavitha1 29

P. Priya Tharshini2 32

P. Udhayarani 45

Parameswari C.S 49

Parthiban. C 25

Prabhakaran.B 28

Premalatha.M 49

Priyadharshini.P 67

Prof. Dr. Seeli Balaji 50


R. Babujanarthanam1 29

R. Sivamani 49, 54, 57

R. Uma2 27

R.Kavitha1 51

R.Murali 48

R.Venkateswari1 46

Revathee. R2 32

Rizwana Begum. S 40


S. Aishwariya2 32

S. Bhuvaneswari 17, 18, 32

S. Iyyam Pillai 34

S. Pradeepa 34

S. Stephen Irudayaraj 47, 66

S. Subramanian 33, 34, 35

S.Latha 67

Saranya.M.K , 62

Sathesh Jayakumar 50

Shyam Krishnan.M1 55

Sivasankari. V 68

Srikala Ganapathy1 37, 59

Suganya Vijayashankar1 48


T. Balasubramanian 25

T.M.Vijayalakshmi 48

T.Naresh 37

T.S.Subha1 46, 51


U.S.Mahadeva Rao 12

Uma. R3 32


V. Kaviyarasan 17, 34

V. Thamizhiniyan 35

V.Vijayakumar1 30

Vidhya C.V 56

Vijayalakshmi Krishnamurthy2 22

Vinoth. D 59
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