Centre d’Etude et de Recherche Médecins d’Afrique




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Centre d’Etude et de Recherche Médecins d’Afrique

www.medecins-afrique.org


Research, Training & Scientific Resources for the Socio-Medical Development of Africa



Ref : CERMA2002E1
In vitro antiplasmodial activity of extracts of Alchornea cordifolia and identification of an active constituent: ellagic acid
J. -T. Banzouzi a, b,e, R. Prado c, H. Menan d, A. Valentin d, C. Roumestan c, M. Mallie d, Y. Pelissier b , Y. Blache a

a- Laboratoire de Chimie Organique Pharmaceutique, E.A. 2414, 15 Avenue Charles Flahault, Faculté de Pharmacie, 34060, Montpellier Cedex 2, France

b- Laboratoire de Pharmacognosie, UFR des Sciences Pharmaceutiques et Biologiques, 15, Av Ch. Flahault, 34060, Montpellier Cedex 2, France

c- Centre de Biochimie Structurale, 15, Av Ch. Flahault, 34060, Montpellier Cedex 2, France

d- Laboratoire d'Immunologie et Parasitologie, UFR des Sciences Pharmaceutiques et Biologiques, 15, Av Ch. Flahault, 34060, Montpellier Cedex 2, France

e- Centre d’Etude et de Recherche Médecins d’Afrique (CERMA), B.P. 45, Brazzaville, Congo




Journal of Ethnopharmacology, 81(3), 399-401 (2002)

Abstract
Extracts of leaves of Alchornea cordifolia were studied for their antiplasmodial activities. Chloroformic and ether extracts were found to be inactive while the ethanolic extract exhibited mild in vitro activity against Plasmodium falciparum. Fractionation of this extract led us to isolate ellagic acid as the active constituent of the extract with IC50 in the range of 0.2–0.5 μM. Cytotoxicity of ethanolic fraction and ellagic acid was also estimated on human fibroblasts cells (IC50 on Hela CELLS=7.3 μM at 24 h for ellagic acid).

Keywords:
Alchornea cordifolia; Antiplasmodial; Ellagic acid


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