Cbs 771: Syllabus Course Co-Coordinators




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CBS 771: Syllabus
Course Co-Coordinators:

Jonathan M. Horowitz, PhD



Office: College of Veterinary Medicine

Research Building, Rm. 354



Office Phone: 515-4479

E-mail address: jon_horowitz@ncsu.edu

Marcelo Rodriguez-Puebla, PhD



Office: College of Veterinary Medicine

Research Building, Rm. 292



Office Phone: 515-7409

E-mail address: marcelo_rodriguez@ncsu.edu@ncsu.edu


Course meeting times: Tuesday, Thursday 3:00-5:00 PM

Office hours: By appointment
Course Prerequisites: CBS 770: Cell Biology (or permission from instructor)

Required Textbook:

The Biology of Cancer

Robert A. Weinberg

2007, Garland Science

ISBN Numbers and costs:

Hardcover (0-8153-4078-8): $140

Paperback (0-8153-4076-1): $81


CANCER BIOLOGY CBS 771 Fall 2007




Course Organization:
The Comparative Biomedical Sciences Graduate Program will offer a course in Cancer Biology. This course will provide a strong foundation in Cancer Biology, using The Biology of Cancer by Robert A. Weinberg as the required text. Lectures will be supplemented with current literature in Cancer Biology, in order to provide students with an understanding of important recent advances in the field.
The course will be team taught by faculty within the Departments of Molecular Biomedical Sciences and Environmental and Molecular Toxicology. Students will be graded based on:
1) class participation (5%),

2) a paper on a selected topic in Cancer Biology (20%),



3) three exams (75%).
Four credits will be earned for this course.

Proposed Class Schedule (Fall 2007)


Lecture #

Date

Lecture Topic/Exam Number










August













L1

23

Chapter 2: Cancer: The problem (Horowitz)




L2,L3

28, 30

Chapters 3 and 4: Tumor viruses and proto-oncogenes (Horowitz)







September










L4,L5

4, 6

Chapter 5: Growth factors/receptors (J. Ninomiya-Tsuji)




L6,L7

11, 18

Chapter 6: Signal transduction (Y. Tsuji)




L8

20

Chapter 7: Tumor-suppressor genes (Horowitz)







25

Exam 1 (L1-L8)



















L9

27

Chapter 8: Rb and G1/S transition (Rodriguez-Puebla)







October













L10

2

Chapter 8: Rb and G1/S transition (Rodriguez-Puebla)




L11,L12

5, 9

Chapter 9: p53 and apoptosis (Horowitz)




L13,L14

16, 18

Chapter 10: Immortalization and telomerase (Rodriguez-Puebla)




L15

23

Chapter 11: Multistep tumorigenesis (Smart)







25

Exam 2 (L9-L15)



















L16

30

Chapter 12: DNA damage and repair mechanisms (Smart)







November










L17

1

Chapter 12: DNA damage and repair mechanisms (Smart)




L18,L19

6, 8

Chapter 13: Stroma/epithelial interactions and angiogenesis (Rodriguez-Puebla)




L20,L21

13, 15

Chapter 14: Invasion and metastasis (Horowitz)




L22

20

Chapter 15: Tumor immunology (Horowitz)




L23,L24

27, 29

Chapter 16: Cancer treatment/drug development(Y. Tsuji)







December










L25

4

Course overview and wrap-up (Horowitz)






















7

Exam 3 (L16-L25)














Lecturers:

Office Phone E-mail Address

Jonathan M. Horowitz, PhD 515-4479 jon_horowitz@ncsu.edu

Marcelo Rodriguez-Puebla, PhD 515-7409 marcelo_rodriguez@ncsu.edu@ncsu.edu

Robert C. Smart, PhD 515-7245 rcsmart@unity.ncsu.edu

Jun Ninomiya-Tsuji, PhD 513-1586 jun_tsuji@ncsu.edu

Yoshi Tsuji, PhD 513-1106 yoshiaki_tsuji@ncsu.edu

Reasonable accommodations will be made for students with verifiable disabilities. Students with disabilities are invited to schedule an appointment with the course coordinators to discuss appropriate accommodations. In order to take advantage of available accommodations, students must register with Disability Services for Students at 1900 Student Health Center, Campus Box 7509, 515-7653. Please see: http://www.ncsu.edu/provost/offices/affirm_action/dss/
For more information on NC State's policy on working with students with disabilities, please see: http://www.ncsu.edu/provost/hat/current/appendix/appen_k.html
Instructor's policies on attendance, (excused and unexcused) absences, and scheduling makeup work will conform to the policies, rules and regulations as outlined here: http://www.ncsu.edu/policies/academic_affairs/courses_undergrad/REG02.20.3.php
Students are expected to abide by the University policy on academic integrity found in the Code of Student Conduct. For more information about the Code please see: http://www.ncsu.edu/policies/student_services/student_discipline/POL11.35.1.php
Lecture materials will be based on concepts presented in relevant chapters in the textbook, although this will be considered as a starting point as course instructors will supplement this material with results from the recent literature.

It is expected that all students will review this material, and any assigned readings, prior to each class.
Grading: Grades will be based on the following:

Exam 1 lectures 1 – 8 25%

Exam 2 lectures 9 – 15 25%

Exam 3 lectures 16 – 25 25%

Research paper see below 20%

Class participation see below 5%


Exams (75%)

Format of exams will be short-answer essay, and questions will be created by each lecturer. Points for each exam will be distributed according to topics covered. Grading concerns must be addressed within one week of exam return.


Research paper (20%)
Students will submit a research paper on a subject relevant to one of the course topics. The body of the paper should be 1500-2500 words and cite current literature. The topic should be pre-approved by at least one instructor and also made known to the course co-coordinators (Drs. Horowitz and Rodriguez-Puebla). The paper will be read and graded independently by two instructors.
Class participation (5%)
Students will be graded on attendance, preparation, and participation in class discussions. Additional work and discussion questions (to be completed outside class) may be assigned by individual instructors.

Final grades will be calculated based on a 9-point scale, with a curve applied as necessary.


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